منابع مشابه
Angiotensin converting enzyme inhibitors.
The purpose of this brief review is to separate the characteristic properties and side effects attributable to the pharmacology of the whole class of angiotensin converting enzyme (ACE) inhibitors from those attributable to the chemical structure and kinetics of each particular ACE inhibitor. The former would be predictable and probably similar for all agents and, therefore, would be expected t...
متن کاملAngiotensin-converting enzyme inhibitors.
ACE inhibitors have achieved widespread usage in the treatment of cardiovascular and renal disease. ACE inhibitors alter the balance between the vasoconstrictive, salt-retentive, and hypertrophic properties of angiotensin II (Ang II) and the vasodilatory and natriuretic properties of bradykinin and alter the metabolism of a number of other vasoactive substances. ACE inhibitors differ in the che...
متن کاملCatalytic antibodies and enzyme inhibitors
Catalytic antibodies or abzymes as we have termed them have generated an avalanche of "forecasts and predictions" concerning their future applications. This, because in principle their only limitations are the designer's creativity and one's ability to access the entire immune systems repertoire. Keeping these so-called predictions in mind, we have sought out a truly formidable test for our de ...
متن کاملAromatase inhibitors and enzyme stability.
The effects of two steroidal (4-hydroxyandrostenedione and atamestane) and three non-steroidal (fadrozole, vorozole, and pentrozole) aromatase inhibitors on the levels of aromatase mRNA and protein were examined in vitro and in vivo. Immunocytochemistry revealed increased quantities of immunoreactive aromatase in human choriocarcinoma-derived JEG-3 cells in response to pretreatment with the non...
متن کاملStudies on Specific Enzyme Inhibitors
In the course of investigations, aiming at the development of enzyme inhibitors to be used as “enzyme reagents” in complex biochemical systems (l-6), special attention was paid to analogues of physiological enzyme substrates which occupy key positions in branching points of metabolic pathways. The present work deals with the chemical and enzyme-inhibitory properties of a hitherto unknown analog...
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ژورنال
عنوان ژورنال: Nature
سال: 1967
ISSN: 0028-0836,1476-4687
DOI: 10.1038/213131a0